![]() To investigate the effect of a combination of Zinc, Chromium, Vitamin C, and Copper supplementation (ZCC supplementation) with standard healthy lifestyle intervention in improving glucose profile ) from prediabetes to normal (reducing the proportion of prediabetes and increasing the proportion to become normal) or reducing the risk of progression from prediabetes to Type 2-Diabetes Mellitus (T2DM) compared to placebo with standard healthy lifestyle intervention. There are several objectives in this study, such as primary objective, secondary objectives, and exploratory objectives. ![]() ![]() Prediabetes is an intermediate stage between normal glucose tolerance and type 2 diabetes mellitus.įurthermore, people with prediabetes have higher risk to develop diabetes mellitus type 2. The primary objective of this study is to investigate the effect of a combination of ZCC supplementation with standard healthy lifestyle counseling in improving glucose profile from prediabetes to normal or reducing the risk of progression from prediabetes to Type 2-Diabetes Mellitus (T2DM) compared to placebo with standard healthy lifestyle intervention.ĭiabetes is an important public health problem as the number of people with diabetes are increasing across the world and contributes to high mortality burden. However, the eficacy of a combined zinc, chromium, vitamin C, and copper (ZCC) in decreasing blood glucose in prediabetic people has never been performed. In addition, vitamin C also contributes in decreasing Fasting Blood Glucose (FBG) and Hemoglobin A1c (HbA1c). Several studies have proven that Zinc and Chromium are minerals that contribute to decreasing the level of blood glucose and insulin resistance. People with prediabetes have higher risk to develop diabetes mellitus type 2. Currently, the incidence of diabetes mellitus is increasing worldwide.
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